Dr. Kenzo Tenma, a leading neurosurgeon at the Dusseldorf Hospital has received massive acclaim for his successful surgery on a famous opera singer. However, he is burdened by guilt. Due to pressure from the director, he had operated on the opera singer on the night that he was supposed to operate on another man. As a result, when the director’s orders him to operate on the mayor, he decides to ignore the order and instead works on saving the life of a young boy, brought to the hospital from the scene of a serial homicide. However, the boy's twin sister, who was brought in with the boy, and who still suffers from shock, keeps repeating the words 'kill him'.

The price for disobeying Dr. Heinemann's orders to operate on the mayor is costly for Dr. Tenma. His career begins to plummet. The boy whom he saved finally awakens, but a horrible incident occurs soon after.

Things look brighter for Dr. Tenma, now that Dr. Heinemann is dead. His career takes off, and even Eva tries to win him back. But unfortunately, all that success has drawn the attention of Detective Lunge.

Adolf Junkers has information about the serial murders that is vital to the police, but he is afraid to reveal them. Dr. Tenma's care for Adolf Junkers however wins him over. His close relationship with Junkers however leads him to a night of shocking horror.

Nina Fortner, a talented young student in Heidelberg has been having nightmares. She also cannot remember anything about her life before she was 10 years old. She soon suffers from fainting spells in university and starts receiving anonymous emails.

Nina finally receives an email informing her to meet the anonymous sender at a specified time and place. Dr. Tenma in his search for the Liebert girl, asks Mauler, an editor for a local publisher, for assistance in his investigations.

Tenma and Nina return to the Fortners’ residence to find Mauler and Nina’s parents dead. Two detectives arrive to take them to the station for questioning, but certain things don't look right.

Eva tries to threaten Dr. Tenma, unless he gets back with her, she would reveal to the police that the tie that was found at the scene of the crime is his!

An old mercenary soldier named Hugo is interrogated by Lunge about a student of his, a doctor named Tenma.

Tenma encounters a burglar named Heckel who claims to have seen the killer. It soon results in Heckel leading Tenma to a couple of murderers.

Tenma learns that Johan used to be in an orphanage known as Kinderheim 511. And he meets a former East German official named Hartmann who used to work there and an injured boy named Dieter.

Dieter is picked up by Hartmann before Tenma could return. And Tenma learns more about the experiments in Kinderheim 511.

In a small village, Dr. Schumann worries over the health of his sick but stubborn old friend, Petra.

Inspector Lunge investigates the murder of a prostitute and suspects a senator named Dr. Boltzmann of involvement. His dedication to his work however takes a toll on his family life. Meanwhile, the vindictive Eva continues to press Lunge to catch Tenma. She also has a new lover, her gardener.

Dr. Tenma and Nina Fortner's investigations lead them to a powerful man known as 'The Baby', who belongs in an extremist organisation. They soon learn that the organisation has special plans for the Turkish district tomorrow.

Nina escapes the mansion. And Tenma meets with the unrecognizable General Wolf at the mansion later.

The extremists plans are put into action, and Tenma decides to postpone his search for Johan and instead heads to the Turkish district to warn the people there. Dieter and Heckel are captured by the skinheads and are left to burn in the fire. And Nina tries to get information about the 'main dish' from 'The Baby'.

Nina meets with an old friend and boss, Mister Rosso. The delightful old boss however, has a very dark past.

Tenma visits Rudy, a criminal psychologist, who is working on cases involving a murderer named Jurgens.

Tenma and Dieter hitch a ride with an elderly couple on the way to Freiham. Tenma wonders if the couple plan to turn him in.

Nina confronts Muller, one of the two detectives responsible for the death of her foster parents, the Fortners. Muller discovers that his protege, Roberto, is actually working for Johan and is now tasked with killing Nina.

Lunge determines that the murder of a wealthy, middle-aged, childless couple does not fit the usual modus operandi of the serial murders and decides to use this opportunity to lure Tenma to a trap. However, before he can arrest him, Lunge is critically wounded by the real criminal. Tenma is able to treat Lunge's injuries.

Eva Heinemann is arrested for public drunkenness and hooks up with Roberto, with whom she was with the night before her arrest. Roberto then reveals his link to Johan and Eva confesses that she was actually a witness the night Junkers was killed by Johan.

In exchange for her life, Roberto tells Eva to confront Tenma, who is currently treating a mob boss at a country house. Eva is promptly wounded by Roberto when she is unable to complete her task but is saved by Tenma.

Karl Neumann and Lotte Frank are both students who read latin to Hans Georg Schubert. Lotte attempts to assist Karl in finding out his past while trying to figure out the identity of a boy who reads to Schubert on Thursdays. When they both discover who he is, they find the boy, Edmund Farren, in his dormitory, dead.

A man who claims to be the son of a millionaire has committed suicide, and a detective is determined to solve the case.

Richard's past and present situation is revealed. Johan continues to bond with the Schuwald family and his intention is revealed.

Richard re-investigates his old homicide cases and makes a frightening discovery.

Robert delves into Johan's past and makes a shocking discovery. Dr. Gillen speaks to Peter Jurgens, a serial murderer about Johan's possible involvement and gets a tragic reply. Johan confronts Robert about Stephen Joos. And Dr. Reichwen receives tragic news from the police.

Suspecting foul play in Robert's 'accidental' death fall, Dr. Reichwen makes some discoveries in his investigations. But as he later realizes, his investigations may have put him in harms way.

Dr. Tenma and Dr. Reichwen finally meet. Dr. Reichwen intends to proof Dr. Tenma's innocence in the homicides, but Dr. Tenma has other ideas.

Lotte, Frank and Karl are drifting apart. Lotte meets Nina Fortner and they become friends. Dr. Tenma searches for a perfect spot to shoot Johan.

Dieter learns of a life threatening game that children are playing. Mr. Schuwald decides to donate his whole book collection to the Munich University Library under the suggestion of Karl and Johan.

The 'Margot Langer' impostor tries to blackmail Johan. Dr. Tenma helps a young 'doctor' at an illegal clinic

Lunge tries to get into Dr. Tenma's mind by pretending to be him. Dr. Gillen learns something about Johan during an interview with a psychotic killer. Dr. Reichwen tries to warn the Lieberts of Johan's true nature. Dr. Tenma scouts for a perfect sniping location.

Dr. Reichwein reveals the true nature of Johan to Mr. Schuwald. Dr. Tenma gets ready to assassinate Johan. Lunge concludes that Dr. Tenma will kill Schuwald next. Lotte confronts Nina about Johan.

The episode begins with a fairy tale about a Monster without a name. Nina reads the story from the picture book and has a sense of deja vu. Johan's evil plans for the book donation ceremony is carried out. Dr. Tenma meets a big obstacle in his attempt to kill Johan.

Dr. Tenma has a gun pointed at Roberto, but Roberto has the rifle pointed at him. Nina, Dr.Reichwen and Dieter arrive to find the whole library in flames. People are trapped inside and the doors are all locked. Karl reads the report on his mother's life and death. Dr. Tenma tries to rescue those trapped in the building. Johan reveals the monster inside of him to Schuwald.

Lunge, from the BKA, learns that Johan may indeed exist. Nina goes into regressive hypnosis to learn more about the picture book and her past. Mr. Schuwald has a message for Dr. Tenma and sends Karl to Dresden to pass it to him.

The episode introduces Grimmer. Grimmer is a freelance journalist doing an in-depth research into the abuses in the orphanages in East Germany. Grimmer meets with Dr. Tenma during their trip to Prague, and they become more acquainted when Tenma is faced with an immigration problem.

Grimmer stubbornly stalks Petrov for his experimental research papers chronicaling the abuses at Kinderheim 511, but he gets a surprise instead.

Grimmer has the key that Petrov gave him, and a former Czechoslovakian secret police organization wants it. Caught and tortured, Grimmer tells his abductors about 'the Magnificent Steiner'.

A new inspector, detective Suk is on the case of Zeman's homicide. During his investigation, he discovers that there is more to Zeman's murder than first assumed. Suk also meets a lady whom he falls head over hills for

After the death of his seniors, Suk is left to re-investigate case from the very beginning. He gets information from the orphans about a meeting with Grimmer. His intention to arrest Grimmer takes a different turn however when he gets deeper into the investigation. The episode also reveals that there is more to the nameless lady at the bar than she lets on.

Suk is put under surveillance by the new commissioner. Together with Grimmer, Suk retrieves the tape and research papers from the deposit box. But their movements is watched by various sides.

Dr. Tenma learns about Suk's fugitive status from a journalist. And sets out to find him. Meanwhile, Suk and Grimmer goes into hiding, but is quickly found, surrounded and attacked by the STB. The STB's assault comes to a bloody end.

Nina's experience in Prague is a nightmare for her. Tenma and Grimmer meets with a top man in the Czechoslovakian STB. They are offered a deal which Grimmer refuses to accept.

Johan visits Suk's mother. Tenma and Grimmer learns of his visit. They, including Col. Ranke, listen to Johan's tape. Lunge arrives in Prague for a 'holiday'. His investigation leads him to the sketches of Franz Bonaparta.

Grimmer and Tenma tries to stop Johan from subjecting Milo, one of the orphans, to one of the most cruel fate.

Lunge investigates the secret behind the Red Rose Mansion. Tenma and Grimmer separate, but Tenma finds himself in trouble.