Kamakshi is entrusted with the responsibility of hunting down the international bootlegger, Furkin, known for smuggling the 'Virgin Mary' artifact from a museum in Paris. In the meanwhile, Interpol agent and Kamakshi's partner, Karoline, land in Pondicherry for a vacation.

Kamakshi discovers that Karoline has been arrested by the police. The police agree to release Karoline in one condition. Karoline and Kamakshi are to pair up and find the drug lord, Furkin and locate the Virgin Mary!

Karoline traps Old Monk, Furkin's partner. However, Kamakshi fails at catching hold of Old Monk and he manages to escape. Karoline and Kamakshi develop disputes and start hating each other.

Later, Kamakshi finds Old Monk but shoots him by mistake. Meanwhile, Furkin's new partner, Vikram, locates Karoline and Kamakshi and starts chasing them.

Furkin's men start chasing Karoline and Kamakshi but the two manage to escape. The two head to the club and Kamakshi gets drunk on alcohol. In the meantime, Furkin and his men reach the club and Kamakshi shoots Furkin!

Furkin's men try to hunt down Karoline and Kamakshi. Karoline is informed about Furkin's men trying to chase them. Karoline and Kamakshi reach a safe place.

Furkin's men find the hideout and reach the spot where Karoline and Kamakshi have been hiding. On the other hand, Furkin learns about the informer, Devaraj and kills him.

The sniper captures Karoline and Kamakshi and shoots Vikram. Karoline and Kamakshi manage to escape from the sniper but get caught in Kunjumohan's search activity. On the other hand, Furkin kills Victoria when he comes to know she was a traitor.

Karoline and Kamakshi continue with their mission after escaping from the cops. They also track Furkin's location and ask Chidambaram for his help for additional force.

As the battle to recover the Virgin Mary continues in full swing, a high voltage fight takes place between Karoline, Kamakshi, and their teams against Furkin’s notorious gang. Who wins the battle?