The Tonight Show with Conan O'Brien kicks it off with actor/comedian Will Ferrell and musical guest Pearl Jam.

The Tonight Show with Conan O'Brien welcomes actor Tom Hanks and musical guest Green Day.

The Tonight Show with Conan O'Brien welcomes actress Julia Louis-Dreyfus, actor Bradley Cooper and musical guest Sheryl Crow.

The Tonight Show with Conan O'Brien welcomes actress Gwyneth Paltrow, The Soup host Joel McHale and musical guest John Mayer Trio.

The Tonight Show with Conan O'Brien welcomes Ryan Seacrest, comedian Patton Oswalt and musical guests Chickenfoot.

The Tonight Show with Conan O'Brien welcomes actor David Duchovny and Anna Friel. Comedian Bill Burr performs.

The Tonight Show with Conan O'Brien welcomes actor Eddie Murphy, Angela Kinsey and musical guest Bonnie Raitt & Taj Mahal.

The Tonight Show with Conan O'Brien welcomes comedian Dane Cook, Steven Ho and musical guest Rancid.

The Tonight Show welcomes comedian Norm MacDonald, comedian Jim Gaffigan and musical guest Neko Case.

The Tonight Show with Conan O'Brien welcomes actor/singer Jamie Foxx and comedian Kevin Nealon. Music performed by Jamie Foxx.

The Tonight Show with Conan O'Brien welcomes Dodgers manager Joe Torre, actor Will Arnett and musical guest Spinal Tap.

The Tonight Show with Conan O'Brien welcomes actor/writer Larry David, Lauren Conrad and musical guest Gavin Rossdale.

The Tonight Show with Conan O'Brien welcomes basketball star Kobe Bryant, actor William Shatner and musical guests Incubus.

The Tonight Show with Conan O'Brien welcomes guests Eva Mendes, Christopher Mintz-Plasse and musical guests The Dead Weather.

The Tonight Show with Conan O'Brien welcomes actor Shia LaBeouf, L.A. Lakers' coach Phil Jackson and musical guest Holly Williams. Triumph, The Insult Comic Dog makes a special report at the Bonnaroo festival.

The Tonight Show with Conan O'Brien welcomes guests Cameron Diaz, Johnny Strange and musical guest Pete Yorn.

The Tonight Show with Conan O'Brien welcomes guests Lisa Kudrow, Billy Mays & Anthony Sullivan and musical guest Elvis Costello.

The Tonight Show with Conan O'Brien welcomes guests Brandon McMillon, Kerry Washington and musical guests Wilco.

The Tonight Show with Conan O'Brien welcomes guests Bruno, Stephen Moyer and a closing performance by Cirque du Soleil Zumanity.

The Tonight Show with Conan O'Brien welcomes guests Snoop Dogg, Jerry Ferrara and musical guest Adele.

The Tonight Show with Conan O'Brien welcomes actor/game show host Howie Mandel, singer Alanis Morissette, and musical performance by Death Cab for Cutie.

The Tonight Show with Conan O'Brien welcomes as guests actor Samuel L. Jackson, actor Kevin Connolly and musical guest Andrew Bird.

The Tonight Show with Conan O'Brien welcomes as guests from the The Today Show Meredith Vieira, from Deadliest Catch Captain Andy Hillstrand and a performance by comedian Al Madrigal.

The Tonight Show with Conan O'Brien welcomes legendary TV host Larry King, actress Zooey Deschanel and musical guests Playing For Change.

The Tonight Show with Conan O'Brien welcomes comedy great Bob Newhart, from So You Think You Can Dance TV show host Cat Deeley and musical guest Ray LaMontagne.

The Tonight Show with Conan O'Brien welcomes guest actor from Law & Order: Criminal Intent Jeff Goldblum, comedian Bill Engvall, and a performance by the cast of Broadway's "Hair."

The Tonight Show with Conan O'Brien welcomes swimming champion Michael Phelps, actress Paget Brewster and musical guests Sugar Ray.

The Tonight Show with Conan O'Brien welcomes actor Dana Carvey, Anthony Anderson and musical performance by Allison Iraheta.

The Tonight Show with Conan O'Brien welcomes actor Gerard Butler, tennis player Venus Williams and musical performance by Daughtry.

The Tonight Show with Conan O'Brien welcomes guest actor Seth Green, Steven Ho and musical guest Demi Lovato.

The Tonight Show with Conan O'Brien welcomes guest actors Adam Sandler, Peter Sarsgaard and musical guest Kate Voegele.

The Tonight Show with Conan O'Brien welcomes guest actor Jonah Hill, actress Cheryl Hines, and comic Dan Naturman.

The Tonight Show with Conan O'Brien welcomes guest actors James Spader and Jack McBrayer and musical guest Mat Kearney.

The Tonight Show with Conan O'Brien welcomes comedian Zach Galifianakis, actress Keke Palmer and musical guest Jason Aldean.

The Tonight Show with Conan O'Brien welcomes actor Seth Rogen, actress Rose Byrne, and musical guest Eric Hutchinson.

The Tonight Show with Conan O'Brien welcomes actress Meryl Streep, film director/producer/writer Judd Apatow and musical guests The Fray.

The Tonight Show with Conan O'Brien welcomes supermodel Heidi Klum, actor Steve Zahn and British comedian Jimmy Carr.

The Tonight Show with Conan O'Brien welcomes actor Rainn Wilson, radio personality Rachel Maddow and musical guests Chicago.

The Tonight Show with Conan O'Brien welcomes Jack Dagger & Tonya Kay, actor Paul Giamatti and musical guest Regina Spektor.

The Tonight Show with Conan O'Brien welcomes actor Hank Azaria, host of "Man v. Food" Adam Richman and musical guest Ben Harper and the Relentless Seven.

The Tonight Show with Conan O'Brien welcomes actor Ashton Kutcher, actress Charlyne Yi, and musical guest Gomez.

The Tonight Show with Conan O'Brien welcomes actor Jeremy Piven, The Human Cannonballs and musical guests the All-American Rejects.

The Tonight Show with Conan O'Brien welcomes actress Sienna Miller, actor and TV show host Steve Schirripa, and a performance by comic Deon Cole.

The Tonight Show with Conan O'Brien welcomes actor Ed Helms and The Jonas Brothers. Both Ed Helms and The Jonas Brothers perform. Also, Conan and Andy take a look into the future... all the way to The Year 3000...

The Tonight Show with Conan O'Brien welcomes Eric Bana, Mary Lynn Rajskub and musical guest Flo Rida.

The Tonight Show with Conan O'Brien welcomes Kyra Sedgwick, Hugh Dancy and musical guest Lyle Lovett and His Large Band.

The Tonight Show with Conan O'Brien welcomes actor Jon Hamm, freestyle motocross athletes Robbie Maddison, Adam Jones and Mike Mason. Musical guests Cobra Starship with Estelle perform.

The Tonight Show with Conan O'Brien welcomes Chef/TV host Gordon Ramsay, actor BJ Novak and micro sculptor Willard Wigan.

The Tonight Show with Conan O'Brien welcomes Robin Williams, Piers Morgan and musical guests All Time Low.

The Tonight Show with Conan O'Brien welcomes NBA superstar Shaquille O'Neil, comic Demitri Martin, and musical performance by Jack Ingram.