Dr. Tenma, Director General of the Science Ministry, loses his son Tobio in an accident. He decides to create the robot Astro Boy, who looks just like Tobio, using the best of the Science Ministry's technology.

It is the year 2000 and robots have been put in charge of making other robots when there are no longer enough people to do the work. Astro Boy dreams of having a real mother, just like human boys. The robot workers are making an experimental new robot named Colosso who goes berserk and escapes shortly after coming to life. The only hope is for Astro Boy to stop him before he cause too much trouble. (In the original Japanese version, Colosso was named "Frankenstein")

Astroboy is selected to lead a search party to find the survivors of the first manned expedition to Mars. This meets strong objection from the spaceship's captain, who protests taking orders from a robot.

Professor Nutty Fruitcake grows giant fruits and vegetables. One day he breeds giant snails thinking they would be harmless, one million snails to be exact. The snails fill the mountain side and overflow into cities.

Astroboy wakes up in the middle of the desert, nearly drained of power and unable to remember how he got there. He is helped by Ali Baba, but in return Astro must battle 'The Sphinx'. This is not a real sphinx, but a robot which guards a desert tomb.

Zero Robot, a blend of Etheric Resin with Clear Plastic, can only be seen with polarized light. Fearless Fred Fenk uses Zero for robbery. Astro Boy once again battles another robot. Defeating Zero at a cost, Astro reassess his role in fighting villians.

Alien resembling aliens including the doctor of Ochanomizu and Higeyajiji emigrated from the stars that looked like the earth in emergency. However, the food crisis and humankind will begin attacking the aliens with cell shrink solution.

In a land called Shangri-Lee a dictator rose to power. Known to his enemies as the Mad Hatter he trusted no one. To solve this need to do everything himself he captured Dr Elefun. Dr Elefun was to make duplicates of the Mad Hatter. Astro Boy rescues Dr Elefun and the Spirit Machine is destroyed.

Crime knows no boundaries - not even the North Pole! Sharkey Dirk and his gang of cut-throats had become the Scourge of the Arctic! An avowed robot-hater, Sharkey foraged far and wide destroying every machine in his path. His hideout was a secret den situated right at the Pole (who would think to look for him there?)

'Lucky' Louie the Lug has slipped by the police at a space port and boarded the first commercial flight to the Moon. Astroboy pursues him seeking to recover stolen diamonds, but the liftoff is underway before he can apprehend the criminal. When meteors collide with the ship, Astro escapes in a damaged space raft with Louie, a little girl named Marvel, Radio Announcer 'Stark' Raving, socialite Mona Toujour and crooked insurance magnate 'Rocco' Gibraltor. They land on a strange asteroid which is a frozen vacuum by night, but has breathable air by day.

One day, excitable Mr. Pompous was relaxing at home when suddenly a mysterious ship crashed through his front door. Clearly the ship was something from the future.

After Dr I.M. Sinister and his 2 henchmen 'Red' and 'Mouse' escape from Sing Song Prison, they hide at the mining colony of Cross Island disguised as robots. The gang overpowers Dr Elefun, who is repairing the robot miners. As chance has it, one boy robot on the island was built by Dr Sinister. While holding Elefun at gunpoint, Sinister demands not only HIS robot but the use of parts from Astroboy, so he can build a super-robot capable of changing into an array of animals.

That priest was dying carving a single mark on the eyes of Christ decorated in the church. Apparently it seems to be a clue to teach the identity of the pirate who broke into the church. The same pirate begins to aim for beard hair that knew their secret.

Film producer Elia Belial plans to ruin Earth using an artificial sun.

Astro runs into two of his friends and stumbles upon an interesting flower. While Astro's friends want to pick it, Astro says to leave the flower alone. He then proceeds to tell the tale of this bizarre flower.

Young Koichi (Tommy Speed) prepares to enter a world race with his supersonic car, the Silver Comet.

Saturn (Baron Von Hoodwink), an evil robot kidnaps Princess Odette (Princess Lollipop), a robot swan who can turn back into her normal self when everyone's asleep. She runs away from Hullabaloo Land as Astro comes to her aid.

A robot centipede disguised as 47 wrestling robots causes havoc on a ship and in the ocean.

Garon, a giant cosmic robot lands on Earth as a meteor, then Astro Boy and the scientists reconstruct him. During a thunderstorm, Garon revives. A corrupt scientist tells Garon to reconstruct an island in the image of his home planet, also changing the atmosphere to match that of the planet, which is toxic to life on Earth.

Astronauts report seeing fireflies in space, but they are really gaseous beings led by the evil Toxor.

At the large space station Satellite R-45, Astro Boy discovers a pair of souvenir vendors hawking stolen wares.

At a beach Astro Boy spots a mysterious bottle with a note calling for rescue from an uncharted island called Sea Serpent Isle.

A mysterious epidemic causes people to drop into comas.

A strange robot demands that Astro Boy and Professor Ochanomizu accompany him to an unknown kingdom at the bottom of the sea.

Together with Dr. Jordan who ran away from under the president who plots world conquest, Atom who got into the underground tank fights the president. But the underground tank loses control and starts pushing towards the volcano.

An evil scientist who hates civilization named Dr. Ram (Don Tay) invents a robot called Atlas to destroy a village.

Time after time, mysterious forces destroy the huge underwater dam being built by the Institute of Science.

Dr. Fooler (Dr. I.Q. Plenty) pitches to some plant owners a machine that makes troublesome robots wacky and therefore harmless. The plant owners accept, and the device affects every robot in the city including Astro Boy.

Once a year, the citizens of Earth celebrate Memory Day and honor the memories of family members who have traveled far into the universe.

A president fears for his life, as the presidents of several other countries have all been attacked by Führer ZZZ (Secret Agent 3-Z).

A monster appears in the city, and it turns out to be Dr. Dorian, who has been exiled to Mars. He turns into a monster because he cannot get cosmic X-rays on the Earth.

Dogs transplanted their brains to the robot are remodeled by Dr. Ponkotsu and challenge humanity as a hot dog corps.

Kino (Abracadabra), a robot magician is approached by a strange magician named Tenpercent, who later frames him for stealing art paintings from a museum. With Astro's help Kino must provide the evidence that he was framed.

The civilized world is shocked to hear of the sighting of a horrific monster.

Astro Boy sets out on a rocket to rescue people who have been kidnapped for use as livestock on a planet.

The religious group Pui Pui is looking for a wonder drug that will give them immortality. Dr. Tatsuji, who has succeeded in developing such a drug, is taken away by the religious group. So Astro Boy fights them to ensure the peaceful use of the drug.

On his birthday, Astro Boy receives a little sister, Uran.

The small planet Mezusa goes out of its orbit and heads straight to the Earth. To save Earth from a collision with the planet, Astro Boy heads for the planet with a convict who is a bomb professional.

Dr. Shisoku despairs of human beings that continue the ongoing destruction of nature, and makes animals attack cities in a machine that hypnotizes with ultra short waves.

Sam Caesar, a mad scientist hopes to create a new Roman Empire.

X Bomb, which is capable of turning any substance to water, drops into the Pacific Ocean. There are 50 hours left until the explosion. Astro Boy goes to recollect it, but learns that Uran, who has followed him, has been swallowed along with the bomb by a whale.

Disguising himself, as a human boy, Astro Boy goes undercover to investigate a drug trade. Some criminals have developed a drug called Yellow Horse, when injected it causes people to dance and make people want more. Professor Ochanomizu has been captured by the drug ring and injected. They try to blackmail him into helping them produce and distribute the drug in exchange for another shot. But Astro is able to pose as a Yellow Horse addict thanks to an artificial skin that makes it look like he is injecting it into himself. He tracks down the headquarters and leads the police to arrest them all. The Professor goes to rehab along with all the addicts for detoxification.

President Ditto (President Rag) is the first robot to lead a nation. His creator Deadcross kidnaps him, and Astro Boy must expose his plot.

Uran is kidnapped and made a hostage in an operation to steal Cleopatra's necklace from Astro Boy. The conspirators believes that whoever possesses the necklace can build the greatest empire in the world.

The gang of conspirators obtains the coveted necklace, and at last sets about conquering the world. Astro Boy stands in the way of their boss, Cleopatra.

The robot spaceship Lever Robot is stolen. Astro Boy is sent to retrieve it, but in the process has his energy stolen.

Astro must destroy a Cosmic Crab (Space Crab) from space.

Nuu, member of the Tenma Tribe, comes from the depths of the mountains of Mongolia. People rush to the city just to see Nuu, throwing the city into a big chaos. Moreover, a gang plots behind the scenes to capture Nuu.

Dr. Hanabusa develops an electrical transmitter for substances. No sooner does he get into the machine for testing that his rival scientist breaks the machine, which makes Dr. Hanabusa an invisible man.

Astro meets Heck Ben, a scientist's son who time travels back to the American wild west to be a cowboy.