Chelsea kicks off a whole new journey of discovery and delinquency with guests Drew Barrymore, Chris Martin and the U.S. secretary of education.

Chelsea talks lube with Gwyneth Paltrow and lobbying with Tony Hale, tests her acting chops in a telenovela, and learns the secret to an ace TED talk.

Chris Evans and the "Civil War" cast dish on superhero culture and Hollywood's blind spots, and Chadwick Boseman schools Chelsea on Black Panther.

Chelsea talks tour life with Gwen Stefani, steps out with a colorful Harajuku squad, and studies the moon with NASA's "Mohawk Guy," Bobak Ferdowsi.

Chelsea delves into the U.S. presidential race with comedian Wanda Sykes, former Obama speechwriter Jon Favreau and a posse of senior Florida voters.

Chelsea reaches for a big note with the Grammy-winning "Voice" coach and steps into the rink with a pair of Russian figure skaters.

Senator Boxer and African-American churchgoers break down what's at stake in the 2016 election. Snapchat guru DJ Khaled preaches the keys to success.

Recovering addicts warn of porn's troubling side effects, and the "Crazy Ex-Girlfriend" star charts her journey from despair to a Golden Globe.

The actor-turned-mogul shares investing tips and joins Cindy McCain to shed light on human trafficking. Chelsea steps out as a dog walker for hire.

Avowed non-parent Chelsea grills Kate Hudson and others about the appeal of raising kids and has her nails done by a gender-nonconforming 9-year-old.

The Science Guy weighs in on Chelsea's cryotherapy experiment and his new thinking on GMOs. "Masters of Sex" star Lizzy Caplan performs a magic trick.

MSNBC's Jacob Soboroff explains the fuss over superdelegates, and astrology maven Megan Fox tries to make sense of mixed signals in Chelsea's chart.

Chelsea dives into a grueling mud race, Will Arnett puts a new spin on Trump's tweets, and "Daily Show" Hasan Minhaj talks Indian toilets.

Chelsea talks threesomes with the 'Do-Over' star, waits tables with her niece, and gets the inside scoop on Melissa Arnot's historic Everest feat.

The rapper joins California Lt. Governor Gavin Newsom to push for game-changing action on pot. Chelsea tries working out stoned with an MMA fighter.

Chelsea delves into the world of "Narcos" with star Wagner Moura and real-life DEA agent Javier Peña. Ariana Huffington warns of sleeping pill risks.

The actress opens up about her LGBT travel show and the devastating toll of the Orlando shooting. Also featuring Florence Henderson, Von Miller.

Chelsea gives Mexican teens a whack at Donald Trump, while Keith Olbermann sizes up the candidate's psyche. Anna Faris and Allison Janney talk Kegels.

"People v. O.J." star Sarah Paulson praises Marcia Clark. Nancy Pelosi calls for action on guns. Jason Biggs and Jenny Mollen share wild travel tales.

"Walking Dead" star Norman Reedus gives Chelsea a taste of motorcycle culture. Strahan talks flirting, good fortune and his new underwear line.

Comedians Adam Devine and Maria Bamford talk stand-ups, psych wards and success. Chelsea tries a mindful coloring session with Metta World Peace.

The actress details a hair-raising outing in Hawaii. Comedian Jim Gaffigan responds to the backlash over his manicure tweet. Plus, modern dating tips.

The country star reveals how girlfriend Gwen Stefani upstaged him on his birthday. Former congressman Barney Frank shares his ideal Democratic ticket.

Alexander Skarsgård reveals his punishing 'Legend of Tarzan' diet, Aubrey Plaza fantasizes about freeing dolphins, and Chelsea studies the red planet.

Chelsea sips mezcal with actor Diego Luna, gets a history lesson from Eva Longoria and grills former Mexican president Fox on bullfighting and Trump.

The 'Mad Max' star opens up about her nontraditional family and dream of stamping out HIV. Jacob Soboroff sizes up VP rumors ahead of the RNC and DNC.

The 'Real Time' host rips into Donald Trump, a former top cop talks police militarization, and Olympian Tony Azevedo reveals racy water polo secrets.

The 'Glee' and '#RichKids' stars talk coming out, gay bars and evolving labels. A transgender woman and her partner share their transitioning story.

The actress responds to 'Ghostbusters' skeptics and flouts fashion norms with her new clothing line. Zachary Quinto celebrates a 'Star Trek' first.

'Suicide Squad' star Adewale Akinnuoye-Agbaje and chef Gordon Ramsay break down Britain's predicament. 'Tickled' lifts the lid on a surreal world.

NeNe Leakes, Clay Aiken and fellow "Celebrity Apprentice" alums dissect the GOP nominee's appeal. Comedian Jim Jefferies poses with male strippers.

Chelsea rents her house out to a Filipino family on Airbnb, Jay Leno relives a hairy crash, and actress Gillian Jacobs shares a terror of improv.

The 'Orphan Black' star shares the secret to playing clones. The Go-Go's reflect on 38 years of fun, fame and fistfights ahead of their farewell tour.

Reese Witherspoon, Common and friends of different faiths open up about their spiritual journeys. Chelsea gets a crash course in religious history.

Emotions run high as Chelsea crashes her first political convention and learns about a civil rights hero. With Jacob Soboroff and David Axelrod.

Jason Biggs hops into the pool with the U.S. men's Olympic water polo team. The irrepressible Denis Leary riffs on his wild past and 27-year marriage.

Chelsea's niece steps in as co-host, and Bryce Dallas Howard offers tips on growing up in a famous family. James Carville marvels at Trump's behavior.

Mayor Aja Brown fights to rebuild a city plagued by turmoil. David Axelrod offers insights on Obama. Michael Kelly talks eerie 'House of Cards' plots.

In the land of vodka, Chelsea braves a bracing spa ritual, tries rhythmic gymnastics with Maria Sharapova and probes the mystery of Russian men.

Chelsea gets sex tips from an adult film icon, talks history with 'Ben-Hur' star Jack Huston and urges the 'American Ninja Warrior' hosts to man up.

The actress reflects on her complex relationship with social media after the death of her father, Robin. Plus, Jon Favreau on Obama's writing habits.

Chelsea asks Tinder CEO Sean Rad for help with her profile and heads into the wilderness for survival school. With Eric André and Joel Kinnaman.

Sparks fly as Chelsea talks cats, fame and Obama with comedian Marc Maron and actress Natasha Lyonne. Plus, Olympic swimming champ Nathan Adrian.

Kate Upton and a crew of YouTube stars discuss the life-changing power of social media. Nasty Gal's Sophia Amoruso shares her wild success story.

Model Ashley Graham and country singer Jana Kramer bond over their brushes with public shaming. Plus, beauty pageant boot camp and comic Jimmy Carr.

Hasan Minhaj of "The Daily Show" recounts his hair-raising trip to the RNC, and the women of "Mr. Robot" celebrate their stereotype-defying roles.

"New Girl" star Max Greenfield hails the joys of fantasy football, Noah Galloway discusses his post-"DWTS" breakup, and Jeff Ross roasts Ann Coulter.

Comedian David Cross mourns the "quaint" early stages of Trump's campaign. Chelsea and "Sully" actor Aaron Eckhart talk phobias and hypnosis.

Chelsea invites a politically diverse group including W. Kamau Bell and S.E. Cupp to dissect the rise of Trump and the issues that divide Americans.

The kids from "Stranger Things" talk sudden fame and welcome a surprise visitor. Abigail Breslin slams an offensive tweet. Plus, comedian Bob Saget.