Michael, dopo una tipica giornata lavorativa, incontra, per puro caso, l’amata ex-moglie, Anna. Situazione del tutto normale se non fosse per un piccolo particolare: la donna, direttrice di un ospedale per poveri, è morta settimane prima a causa di un incidente stradale. Il razionale medico Holt, appena sa della scioccante notizia, cade in una profonda crisi spezzata dalla comparsa dell’ex-moglie, durante una visione, che gli spiega il perché di quella visita sopranaturale: vorrebbe che lui curasse i suoi, ormai, ex-pazienti, bisognosi di cure ma privi di mezzi economici per pagarle. Michael accetterà la richiesta di Anna?

Michael troverà la propria vita personale intrecciata a quella lavorativa: verrà, difatti, diagnosticato, ad una sua cara amica in dolce attesa, un tumore cerebrale e l’esperto medico si troverà a lottare per salvarle la vita. Nel frattempo, si presenterà alla porta di Holt il caso di un bambino affetto da un’anemia a cellule falciformi.

Il dr. Michael e' alle prese con una donna che ha delle inspiegabile lesioni cerebrali e si ritrova alla prese con gente molto, molto povera...

Un ragazzo chiede aiuto al dr. Mlchael Holt perche' sente delle voci. Michael, sua volta, chiede aiuto ad Anton per un consiglio spirituale...

Michael must decide if it is worth risking his practice to save a patient's life. Meanwhile, he courts Evan "E-Mo" Morris, a neuropsychiatrist to join his practice after E-Mo determines a patient's diagnosis by reading her body language.

While at the clinic, Michael runs into a former football star that he performed successful surgery on years ago, and is now a shell of his former self, living on the streets. At Holt Neuro, Michael examines a patient who suffers from post-traumatic stress disorder.

When Michael finds out a patient with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life. Meanwhile, a female firefighter who appears to be disoriented is brought to Holt Neuro for evaluation.

In this holiday episode, the staff at Clinica Sonando celebrates Thanksgiving. Meanwhile, Michael must save the life of Rita’s son. who is injured in a motorcycle accident after returning for a Thanksgiving reunion with his family.

Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.

While tending to patients at the clinic during a blizzard, Michael shows signs of a severe condition that requires immediate surgery.

Michael and E-Mo clash over a patient's treatment; a teenager abandons her baby at the clinic after giving birth.

Michael saves a man from drowning and learns his identity is a mystery. Meanwhile, Kate discovers a girl she mentors has serious issues that she has failed to notice.

A distraught woman takes the Clinica staff hostage after Michael testifies for a former patient who he believed suffered uncontrollable urges due to a brain tumor.

When a spoiled pop star comes to Holt Neuro experiencing unusual symptoms, and a young girl at the Clinica exhibits similar symptoms on the same day, it forces both teams of doctors to try and piece together their common link.

When Michael's high school sweetheart comes to Holt Neuro with an irreversible condition, he will stop at nothing to try and save her, until Anna intervenes. Meanwhile, Zeke deals with the news that his best friend's cancer has returned.

Michael learns that a patient at the clinic has a special connection to Anna. Meanwhile, Michael reunites with an old friend who is suffering from a rare illness.